While innate immunity is vital for clearing pathogens, its unchecked activation can sometimes inflict unintended harm on our tissues and organs. Thus, maintaining a delicate equilibrium in immune responses becomes crucial for overall homeostasis.

In instances of immune system hyperactivity, an excess release of cytokines into the bloodstream triggers a phenomenon known as a cytokine storm. This cascade of heightened immune signaling involves major cytokines like TNF and IFN-γ. When these cytokines collaborate, they can induce cell death, setting off a perilous positive feedback loop that further escalates cytokine release. This storm of cytokines can wreak havoc on vital organs, such as the lungs and liver, leading to significant collateral damage.

Several diseases, including COVID-19, CAR-T cell therapy complications, and the autoimmune condition HLH (Hemophagocytic Lymphohistiocytosis), have been associated with cytokine storm manifestations. We have showcased the potential of neutralizing TNF and IFN-γ in preventing or curing COVID-19. Building on this discovery, our primary aim is to explore the broader applicability of this approach across other cytokine storm-related diseases.

Join us as we delve deeper into understanding these intricate immune responses and investigate innovative strategies that could potentially revolutionize the treatment landscape for cytokine storm-associated ailments, paving the way for more effective therapeutic interventions and improved patient outcomes.