"Cutting Edge: Caspase-8 Is a Linchpin in Caspase-3 and Gasdermin D Activation to Control Cell Death, Cytokine Release, and Host Defense during Influenza A Virus Infection"

Yaqiu Wang, Rajendra Karki, Min Zheng, Balabhaskararao Kancharana, SangJoon Lee, Sannula Kesavardhana, Baranda S Hansen, Shondra M Pruett-Miller, Thirumala-Devi Kanneganti, The Journal of immunology, 2021 Nov, 207(10), 2411-2416

"Ets-2 deletion in myeloid cells attenuates IL-1α-mediated inflammatory disease caused by a Ptpn6 point mutation"

Sarang Tartey, Prajwal Gurung, Rajendra Karki, Amanda Burton, Paul Hertzog, Thirumala-Devi Kanneganti, Cellular and molecular immunology, 2021 Jul, 18(7), 1798-1808

"DDX3X coordinates host defense against influenza virus by activating the NLRP3 inflammasome and type I interferon response"

Sannula Kesavardhana, Parimal Samir, Min Zheng, R K Subbarao Malireddi, Rajendra Karki, Bhesh Raj Sharma, David E Place, Benoit Briard, Peter Vogel, Thirumala-Devi Kanneganti, The Journal of biological chemistry, 2021 Jan-Jun, 296:100579,

"TLR2 senses the SARS-CoV-2 envelope protein to produce inflammatory cytokines"

Min Zheng, Rajendra Karki, Evan Peter Williams, Dong Yang, Elizabeth Fitzpatrick, Peter Vogel, Colleen Beth Jonsson, Thirumala-Devi Kanneganti, Nature immunology, 2021 Jul, 22(7):829-838,

"The 'cytokine storm': molecular mechanisms and therapeutic prospects"

Rajendra Karki , Thirumala-Devi Kanneganti, 2021 Aug, 42(8), 681-705

"Caspase-6 promotes activation of the caspase-11-NLRP3 inflammasome during gram-negative bacterial infections"

Min Zheng, Rajendra Karki, Balabhaskararao Kancharana, Hartmut Berns, Shondra M Pruett-Miller, Thirumala-Devi Kanneganti, The Journal of biological chemistry, 2021 Dec, 297(6):, 101379

"Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes"

Rajendra Karki, Bhesh Raj Sharma, Shraddha Tuladhar, Evan Peter Williams, Lillian Zalduondo, Parimal Samir, Min Zheng, Balamurugan Sundaram, Balaji Banoth, R K Subbarao Malireddi, Patrick Schreiner, Geoffrey Neale, Peter Vogel , Richard Webby, Colleen Bet, Cell. 2021 Jan,

"Interferon inducible GBPs restrict Burkholderia thailandensis motility induced cell-cell fusion"

David E Place, Benoit Briard, Parimal Samir, Rajendra Karki, Anannya Bhattacharya, Clifford S Guy, Jennifer L Peters, Sharon Frase, Peter Vogel, Geoffrey Neale, Masahiro Yamamoto, Thirumala-Devi Kanneganti,, PLoS Pathogens, 2020 Mar, 16(3), e1008364

"IRF8 regulates gram-negative bacteria-mediated NLRP3 inflammasome activation and cell death"

Rajendra Karki#, Ein Lee#, Bhesh R Sharma#, Balaji Banoth, Thirumala-Devi Kanneganti, Journal of Immunology, 2020 May, 204(9), 2514-2522

"The nonreceptor tyrosine kinase SYK drives caspase-8/NLRP3 inflammasome-mediated autoinflammatory osteomyelitis"

Tejasvi K Dasari, Rechel Geiger, Rajendra Karki, Blaji Banoth, Bhesh Raj Sharma, Prajwal Gurung, Amanda Burton, Thirumala-Devi Kanneganti, Journal of Biological Chemistry, 2020 Mar, 295(11), 3394-3400

"Galactosaminogalactan activates the inflammasome to provide host protection"

Briard B, Fontaine T, Samir P, Place DE, Muszkieta L, Malireddi RKS, Karki R, Christgen S, Bomme P, Vogel P, Beau R, Mellado E, Ibrahim-Granet O, Henrissat B, Kalathur RC, Robinson C, Latgé JP, Kanneganti TD., Nature, 2020 Dec, 588(7839), 688-692

"RIPK1 Distinctly Regulates Yersinia-Induced Inflammatory Cell Death, PANoptosis"

R K Subbarao Malireddi, Sannula Kesavardhana, Rajendra Karki, Balabhaskararao Kancharana, Amanda R Burton, Thirumala-Devi Kanneganti, ImmunoHorizons, 2020 Dec, 4(12), 789-796

"Identification of the PANoptosome: A Molecular Platform Triggering Pyroptosis, Apoptosis, and Necroptosis (PANoptosis)"

Shelbi Christgen, Min Zheng 1, Sannula Kesavardhana 1, Rajendra Karki 1, R K Subbarao Malireddi 1, Balaji Banoth 1, David E Place 1, Benoit Briard 1, Bhesh Raj Sharma 1, Shraddha Tuladhar 1, Parimal Samir 1, Amanda Burton 1, Thirumala-Devi Kanneganti 1, Frontiers in Cellular and Infection Microbiology, 2020 May, 10:237,

"Impaired NLRP3 inflammasome activation/pyroptosis leads to robust inflammatory cell death via caspase-8/RIPK3 during coronavirus infection"

Min Zheng, Evan Peter Williams, R K Subbarao Malireddi, Rajendra Karki, Balaji Banoth, Amanda Burton, Richard Webby, Rudragouda Channappanavar, Colleen Beth Jonsson, Thirumala-Devi Kanneganti, Journal of Biological Chemistry, 2020 Oct, 295(41), 14040-14052

"Interferon regulatory factor 1 regulates PANoptosis to prevent colorectal cancer"

Rajendra Karki, Bhesh Raj Sharma, Ein Lee, Balaji Banoth, R K Subbarao Malireddi, Parimal Samir, Shraddha Tuladhar, Harisankeerth Mummareddy, Amanda R Burton, Peter Vogel, Thirumala-Devi Kanneganti, JCI Insight, 2020 Jun, 5(12), e136720