"Innate immune sensing of dietary alcohol ignites inflammation to drive alcohol-related disease"

Yeonseo Jang†, Hoeun Bae†, SuHyeon Oh†, Gyeongju Yu†, Hyun Bae , Minh Quan Nguyen , Raghvendra Mall , Minjie Fu , Aritra Ghosh , Jihye Lee , Suhyun Kim , Seyun Shin , Nabukenya Mariam , Cheong Seok , Daesik Kim, SangJoon Lee*, Si Ming Man*, Rajendra Karki*, Science Advances, 2026, 12, nn

"XMolCap: Advancing Molecular Captioning Through Multimodal Fusion and Explainable Graph Neural Networks"

Duong Thanh Tran, Nguyen Doan Hieu Nguyen, Nhat Truong Pham, Rajan Rakkiyappan, Rajendra Karki, Balachandran Manavalan*, 2025, (10), 7034-7045

"A potent NLRP3 inhibitor effective against both MCC950-sensitive and -resistant inflammation"

Wonyoung Kim#, Soyeon Kim# , Hawon Woo, Renuka Anil Jojare, Raghvendra Mall, Asia Nicotra, Benedicte F Py, Chinh Ngo, Si Ming Man, Chirag N Patel*, Rajendra Karki*, Cell chemical biology, 2025, 32(9), 1125-1139

"The NSP5, ORF6 and NSP13 of SARS-CoV-2 Cooperate to Modulate Inflammatory Cell Death Activation"

Huan Wang , Mengdi Liang , Jing Zhang, Hua Tong , Fenfen Zhang , Ying Liu , Pui Wang , Mengmeng Chang , Fei Han , Siwen Liu , Yongping Lin , Wenjun Song , Rajendra Karki , Peihui Wang , Honglin Chen , Yang Liu, Min Zheng, Advanced science, 2025, e03977

"Ferroptosis-activating metabolite acrolein antagonizes necroptosis and anti-cancer therapeutics"

Hyun Bae#, Seonghyun Moon#, Mengmeng Chang, Fenfen Zhang, Yeonseo Jang, Wonyoung Kim, Soyeon Kim, Minjie Fu, Jaemin Lim, Seongjun Park, Chirag N Patel, Raghvendra Mall, Min Zheng, Si Ming Man*, Rajendra Karki*, Nature Communications, 2025 May, 16(1), 4919

"DNA sensors in metabolic and cardiovascular diseases: Molecular mechanisms and therapeutic prospects"

Hyosang Kwak#, Ein Lee#, Rajendra Karki, Immunological reviews, 2024 Aug,

"Implications of inflammatory cell death-PANoptosis in health and disease"

Hyun Bae#, Yeonseo Jang#, Rajendra Karki* & Joo-Hui Han*, Archives of Pharmacal Research, 2024 Jul, 47(7), 617-631

"A comparative study of apoptosis, pyroptosis, necroptosis, and PANoptosis components in mouse and human cells"

Sk Mohiuddin Choudhury, Roman Sarkar, Rajendra Karki, Thirumala-Devi Kanneganti, Public Library of Science one, 2024 Feb, 19(2), e0299577

"Inhibition of the RPS6KA1/FoxO1 signaling axis by hydroxycitric acid attenuates HFD-induced obesity through MCE suppression"

Hyung-Won Lee, Rajendra Karki , Joo-Hui Han, Phytomedicine : international journal of phytotherapy and phytopharmacology, 2024, 128, 155551

"NINJ1 mediates inflammatory cell death, PANoptosis, and lethality during infection conditions and heat stress"

Joo-Hui Han #, Rajendra Karki #, R K Subbarao Malireddi, Raghvendra Mall , Roman Sarkar, Bhesh Raj Sharma , Jonathon Klein, Harmut Berns , Harshan Pisharath, Shondra M Pruett-Miller, Sung-Jin Bae , Thirumala-Devi Kanneganti, Nature Communications, 2024, 15(1), 1739

"Immune regulator IRF1 contributes to ZBP1-, AIM2-, RIPK1-, and NLRP12-PANoptosome activation and inflammatory cell death (PANoptosis)"

Sharma B.R.; Karki R.; Rajesh Y.; Kanneganti T.-D., The Journal of biological chemistry, 2023 Sep, 299(9), 105141

"NLRP12-PANoptosome activates PANoptosis and pathology in response to heme and PAMPs"

Sundaram B.; Pandian N.; Mall R.; Wang Y.; Sarkar R.; Kim H.J.; Malireddi R.K.S.; Karki R.; Janke L.J.; Vogel P.; Kanneganti T.-D., Cell, Jun 22, 186(13), 2783-2801

"PANoptosome signaling and therapeutic implications in infection: central role for ZBP1 to activate the inflammasome and PANoptosis"

Karki R.; Kanneganti T.-D., Current Opinion in Immunology, 2023 Aug, 83, 102348

"ADAR1 and ZBP1 in innate immunity, cell death, and disease"

Karki R.; Kanneganti T.-D., Trends in Immunology, 2023 Mar, 44(3), 201-216

"Regulated cell death pathways and their roles in homeostasis, infection, inflammation, and tumorigenesis"

Lee, Ein#; Song, Chang-Hyun#; Bae, Sung-Jin; Ha, Ki-Tae; Karki, Rajendra∗, Experimental and Molecular Medicine, 2023 Aug, 55(8), 1632-1643